2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13637R
    Ganciclovir (Standard)
    Ganciclovir (Standard) is the analytical standard of Ganciclovir. This product is intended for research and analytical applications. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
    Ganciclovir (Standard)
  • HY-137614C
    Rp-GTPαS tetrasodium
    Rp-GTPαS tetrasodium is a phosphorothioate analogue of Guanosine triphosphate (GTP) (HY-113225) that can activate calcium release and secretion in single rat peritoneal mast cells.
    Rp-GTPαS tetrasodium
  • HY-171521
    LNA-GDP
    LNA-GDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-GDP
  • HY-W1119950
    3'-NH-Tr-2',3'-DMF-ddA- 5'-CE-Phosphoramidite
    3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite is an adenine nucleotide monomer precursor used in solid-phase synthesis of oligonucleotides, particularly modified oligonucleotides, such as those with DNA chain end modifications. 3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite, with trityl (Tr), cyanoethyl (CE), and dimethylformamidine (DMF) protecting groups, is a ddNTP adenosine nucleoside useful in applications such as solid-phase oligonucleotide synthesis, probe design, and chain-termination sequencing.
    3'-NH-Tr-2',3'-DMF-ddA- 5'-CE-Phosphoramidite
  • HY-131804A
    3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate tetrasodium
    3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate (3'-O-Ac-dCTP) tetrasodium is a nucleoside triphosphate derivative with potential applications in DNA synthesis and nucleoside drug design. 3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate tetrasodium can be used to inhibit chain elongation reactions and as a terminator or biochemical probe.
    3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate tetrasodium
  • HY-134278A
    8-Bromoinosine-5'-O-triphosphate tetrasodium
    8-Bromoinosine-5'-O-triphosphate (8-Br-ITP) tetrasodium is a derivative of the nucleoside triphosphate Inosine-5'-triphosphate (ITP) (HY-W013706). 8-Bromoinosine-5'-O-triphosphate tetrasodium can be used in the determination of nucleoside diphosphate kinase (NDPK) activity.
    8-Bromoinosine-5'-O-triphosphate tetrasodium
  • HY-171525
    2'-F-CDP
    2'-F-CDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-F-CDP
  • HY-13677R
    6-Mercaptopurine (Standard)
    		Antagonist
    6-Mercaptopurine (Standard) is the analytical standard of 6-Mercaptopurine. This product is intended for research and analytical applications. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.
    6-Mercaptopurine (Standard)
  • HY-122524A
    7-Methylguanosine iodide
    		Inhibitor
    7-Methylguanosine iodide is an iodide of 7-Methylguanosine (HY-122524). 7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects.
    7-Methylguanosine iodide
  • HY-131611R
    6-Azuridine (Standard)
    6-Azuridine (Standard) is the analytical standard of 6-Azuridine. This product is intended for research and analytical applications. 6-Azuridine (6-Azauridine) is an orally active purine nucleoside analogue. 6-Azuridine activates autophagic flux, induces Apoptosis that depends on AMPK and p53. 6-Azuridine exhibit both antitumor and antiviral activities.
    6-Azuridine (Standard)
  • HY-137696A
    ddCTPαS tetrasodium
    ddCTPαS tetrasodium is a dideoxynucleotide that can be used for DNA sequencing.
    ddCTPαS tetrasodium
  • HY-47351
    N-Acetyl-2',3'-acetyl-guanosine
    N-Acetyl-2', 3'-Acetyl-Guanosine is a modified guanosine nucleoside.
    N-Acetyl-2',3'-acetyl-guanosine
  • HY-137693A
    ddTTPαS tetrasodium
    ddTTPαS tetrasodium is a sulfur-containing nucleoside triphosphate derivative. ddTTPαS tetrasodium can be used for chain extension in PCR assays.
    ddTTPαS tetrasodium
  • HY-154255
    5-(3-Azidopropyl)uridine
    5-(3-Azidopropyl)uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. 5-(3-Azidopropyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5-(3-Azidopropyl)uridine
  • HY-173579
    2'(3')-O-(2-Aminoethylcarbamoyl)adenosine-5'-O-diphosphate trisodium
    2'(3')-O-(2-Aminoethylcarbamoyl)adenosine-5'-O-diphosphate (2'(3')-AEC-ADP) trisodium is a derivative of Adenosine 5'-diphosphate (ADP) (HY-W010918).
    2'(3')-O-(2-Aminoethylcarbamoyl)adenosine-5'-O-diphosphate trisodium
  • HY-W091784R
    3'-O-Methylguanosine (Standard)
    3'-O-Methylguanosine (Standard) is an analytical standard of 3'-O-Methylguanosine (HY-W091784). This product is intended for research and analytical applications. 3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA.
    3'-O-Methylguanosine (Standard)
  • HY-W608384
    Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite
    Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
    Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite
  • HY-B0069R
    Fludarabine (Standard)
    		Inhibitor
    Fludarabine (Standard) is the analytical standard of Fludarabine. This product is intended for research and analytical applications. Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.
    Fludarabine (Standard)
  • HY-137733A
    CDP-β-S trisodium salt
    CDP-β-S (Cytidine-5'-O-(2-thiodiphosphate)) trisodium salt is an unhydrolyzable analogue of CDP (Cytidine Diphosphate), featuring antioxidant and free radical scavenging functions.
    CDP-β-S trisodium salt
  • HY-177199
    2'-OMe-4'-ODMT-5'-NO2 phenoxybutyric acid
    2'-OMe-4'-ODMT-5'-NO2 phenoxybutyric acid is a phosphonamide acid that can be used in nucleic acid synthesis.
    2'-OMe-4'-ODMT-5'-NO2 phenoxybutyric acid